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tajima s d value  (Tajima Shoji Co Ltd)
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Laboratory parameter trajectories around ECMO circuit exchange, stratified by major bleeding status. ( A ) <t>D-dimer,</t> platelet count, fibrinogen, and hemoglobin trajectories. D-dimer values are censored at the upper detection limit of 35.2 mg/L. ( B ) INR, aPTT, free hemoglobin, and post-oxygenator PO 2 trajectories. Data from 93 ECMO circuit exchange episodes in 35 patients, stratified by occurrence of major bleeding during the 15-day observation period (red, n = 29) versus no major bleeding (blue, n = 64). Lines represent medians; shaded areas, interquartile range. Day 0 (dashed line) indicates circuit exchange. Numbers denote sample size at each timepoint. Cases with major bleeding showed lower platelet counts and fibrinogen levels, with a nadir around the day of exchange, whereas D-dimer levels peaked at exchange. Both groups demonstrated partial recovery of coagulation parameters following circuit exchange. Abbreviations: INR , international normalized ratio; aPTT , activated partial thromboplastin time , Hb , hemoglobin.
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d values  (Tajima Shoji Co Ltd)
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Laboratory parameter trajectories around ECMO circuit exchange, stratified by major bleeding status. ( A ) <t>D-dimer,</t> platelet count, fibrinogen, and hemoglobin trajectories. D-dimer values are censored at the upper detection limit of 35.2 mg/L. ( B ) INR, aPTT, free hemoglobin, and post-oxygenator PO 2 trajectories. Data from 93 ECMO circuit exchange episodes in 35 patients, stratified by occurrence of major bleeding during the 15-day observation period (red, n = 29) versus no major bleeding (blue, n = 64). Lines represent medians; shaded areas, interquartile range. Day 0 (dashed line) indicates circuit exchange. Numbers denote sample size at each timepoint. Cases with major bleeding showed lower platelet counts and fibrinogen levels, with a nadir around the day of exchange, whereas D-dimer levels peaked at exchange. Both groups demonstrated partial recovery of coagulation parameters following circuit exchange. Abbreviations: INR , international normalized ratio; aPTT , activated partial thromboplastin time , Hb , hemoglobin.
D Values, supplied by Tajima Shoji Co Ltd, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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significant negative tajima s d values  (Tajima Shoji Co Ltd)
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Laboratory parameter trajectories around ECMO circuit exchange, stratified by major bleeding status. ( A ) <t>D-dimer,</t> platelet count, fibrinogen, and hemoglobin trajectories. D-dimer values are censored at the upper detection limit of 35.2 mg/L. ( B ) INR, aPTT, free hemoglobin, and post-oxygenator PO 2 trajectories. Data from 93 ECMO circuit exchange episodes in 35 patients, stratified by occurrence of major bleeding during the 15-day observation period (red, n = 29) versus no major bleeding (blue, n = 64). Lines represent medians; shaded areas, interquartile range. Day 0 (dashed line) indicates circuit exchange. Numbers denote sample size at each timepoint. Cases with major bleeding showed lower platelet counts and fibrinogen levels, with a nadir around the day of exchange, whereas D-dimer levels peaked at exchange. Both groups demonstrated partial recovery of coagulation parameters following circuit exchange. Abbreviations: INR , international normalized ratio; aPTT , activated partial thromboplastin time , Hb , hemoglobin.
Significant Negative Tajima S D Values, supplied by Tajima Shoji Co Ltd, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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d value  (Tajima Shoji Co Ltd)
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Tajima Shoji Co Ltd d value
Laboratory parameter trajectories around ECMO circuit exchange, stratified by major bleeding status. ( A ) <t>D-dimer,</t> platelet count, fibrinogen, and hemoglobin trajectories. D-dimer values are censored at the upper detection limit of 35.2 mg/L. ( B ) INR, aPTT, free hemoglobin, and post-oxygenator PO 2 trajectories. Data from 93 ECMO circuit exchange episodes in 35 patients, stratified by occurrence of major bleeding during the 15-day observation period (red, n = 29) versus no major bleeding (blue, n = 64). Lines represent medians; shaded areas, interquartile range. Day 0 (dashed line) indicates circuit exchange. Numbers denote sample size at each timepoint. Cases with major bleeding showed lower platelet counts and fibrinogen levels, with a nadir around the day of exchange, whereas D-dimer levels peaked at exchange. Both groups demonstrated partial recovery of coagulation parameters following circuit exchange. Abbreviations: INR , international normalized ratio; aPTT , activated partial thromboplastin time , Hb , hemoglobin.
D Value, supplied by Tajima Shoji Co Ltd, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Laboratory parameter trajectories around ECMO circuit exchange, stratified by major bleeding status. ( A ) D-dimer, platelet count, fibrinogen, and hemoglobin trajectories. D-dimer values are censored at the upper detection limit of 35.2 mg/L. ( B ) INR, aPTT, free hemoglobin, and post-oxygenator PO 2 trajectories. Data from 93 ECMO circuit exchange episodes in 35 patients, stratified by occurrence of major bleeding during the 15-day observation period (red, n = 29) versus no major bleeding (blue, n = 64). Lines represent medians; shaded areas, interquartile range. Day 0 (dashed line) indicates circuit exchange. Numbers denote sample size at each timepoint. Cases with major bleeding showed lower platelet counts and fibrinogen levels, with a nadir around the day of exchange, whereas D-dimer levels peaked at exchange. Both groups demonstrated partial recovery of coagulation parameters following circuit exchange. Abbreviations: INR , international normalized ratio; aPTT , activated partial thromboplastin time , Hb , hemoglobin.

Journal: Scientific Reports

Article Title: Daily biomarker trajectories predict major bleeding in patients on venovenous ECMO for ARDS: a retrospective longitudinal cohort study

doi: 10.1038/s41598-026-47560-0

Figure Lengend Snippet: Laboratory parameter trajectories around ECMO circuit exchange, stratified by major bleeding status. ( A ) D-dimer, platelet count, fibrinogen, and hemoglobin trajectories. D-dimer values are censored at the upper detection limit of 35.2 mg/L. ( B ) INR, aPTT, free hemoglobin, and post-oxygenator PO 2 trajectories. Data from 93 ECMO circuit exchange episodes in 35 patients, stratified by occurrence of major bleeding during the 15-day observation period (red, n = 29) versus no major bleeding (blue, n = 64). Lines represent medians; shaded areas, interquartile range. Day 0 (dashed line) indicates circuit exchange. Numbers denote sample size at each timepoint. Cases with major bleeding showed lower platelet counts and fibrinogen levels, with a nadir around the day of exchange, whereas D-dimer levels peaked at exchange. Both groups demonstrated partial recovery of coagulation parameters following circuit exchange. Abbreviations: INR , international normalized ratio; aPTT , activated partial thromboplastin time , Hb , hemoglobin.

Article Snippet: D-dimer values were measured using the Innovance D-dimer assay (Siemens Healthineers, Marburg, Germany) and censored at the upper detection limit of 35.2 mg/L.

Techniques: Coagulation

Multivariable time-lagged predictors of major bleeding during ECMO support. Adjusted odds ratios (95% CI) per 1-SD increase from multivariable generalized linear mixed models including D-dimer, fibrinogen, platelet count, and white blood cell count simultaneously at each lag interval. Filled circles indicate p < 0.05; open circles indicate non-significant associations. Green shading highlights the 1–3 day predictive window. D-dimer showed a narrow 1–2 day predictive window, whereas WBC demonstrated a broader 1–4 day window, suggesting temporally complementary contributions of coagulopathy and inflammation to bleeding risk. Platelet count was not independently predictive at any lag. All models adjusted for intervention phase and time with nested random intercepts for episodes within patients. Abbreviations: CI, confidence interval; OR, Odds ratio; WBC, white blood cell count.

Journal: Scientific Reports

Article Title: Daily biomarker trajectories predict major bleeding in patients on venovenous ECMO for ARDS: a retrospective longitudinal cohort study

doi: 10.1038/s41598-026-47560-0

Figure Lengend Snippet: Multivariable time-lagged predictors of major bleeding during ECMO support. Adjusted odds ratios (95% CI) per 1-SD increase from multivariable generalized linear mixed models including D-dimer, fibrinogen, platelet count, and white blood cell count simultaneously at each lag interval. Filled circles indicate p < 0.05; open circles indicate non-significant associations. Green shading highlights the 1–3 day predictive window. D-dimer showed a narrow 1–2 day predictive window, whereas WBC demonstrated a broader 1–4 day window, suggesting temporally complementary contributions of coagulopathy and inflammation to bleeding risk. Platelet count was not independently predictive at any lag. All models adjusted for intervention phase and time with nested random intercepts for episodes within patients. Abbreviations: CI, confidence interval; OR, Odds ratio; WBC, white blood cell count.

Article Snippet: D-dimer values were measured using the Innovance D-dimer assay (Siemens Healthineers, Marburg, Germany) and censored at the upper detection limit of 35.2 mg/L.

Techniques: Cell Characterization